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Rsph4atm1.1Hmd
Targeted Allele Detail
Summary
Symbol: Rsph4atm1.1Hmd
Name: radial spoke head 4 homolog A (Chlamydomonas); targeted mutation 1.1, Hiroshi Hamada
MGI ID: MGI:5882201
Synonyms: Rsph4atm1.1Kys
Gene: Rsph4a  Location: Chr10:33781107-33792017 bp, + strand  Genetic Position: Chr10, 18.84 cM
Alliance: Rsph4atm1.1Hmd page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:239950
Parent Cell Line:  G4 (ES Cell)
Strain of Origin:  (129S6/SvEvTac x C57BL/6NCrl)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: LoxP sites were inserted into introns 1 and 3. An FRT site flanked neomycin resistance gene cassette was inserted between exon 3 and the loxP site. Through subsequent cre-mediated recombination, exons 2 and 3 as well as the neo cassette were deleted, creating a null allele. (J:239950)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Rsph4a Mutation:  41 strains or lines available
References
Original:  J:239950 Shinohara K, et al., Absence of Radial Spokes in Mouse Node Cilia Is Required for Rotational Movement but Confers Ultrastructural Instability as a Trade-Off. Dev Cell. 2015 Oct 26;35(2):236-46
All:  3 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory