Tg(Cdh5-cre,-GFP)21Msri
Transgene Detail
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| Symbol: |
Tg(Cdh5-cre,-GFP)21Msri |
| Name: |
transgene insertion 21, Michele Souyri |
| MGI ID: |
MGI:5882215 |
| Synonyms: |
Tg(Cdh5-cre,-GFP)21, VEC |
| Transgene: |
Tg(Cdh5-cre,-GFP)21Msri Location: unknown
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| Alliance: |
Tg(Cdh5-cre,-GFP)21Msri page
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| Strain of Origin: |
Not Specified
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| Transgene Type: |
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Transgenic (Recombinase, Reporter) |
| Mutation: |
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Insertion
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Tg(Cdh5-cre,-GFP)21Msri expression driven by
1 gene
Transgene expression driven by:
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Mutation details: Mice with this transgene express Cre recombinase under the control of the regulatory sequences of mouse cadherin 5 (also called vascular endothelial cadherin) residing between ~2500 base pairs upstream of the translation initiation codon and the middle of the first intron, wherein resides an enhancer sequence. The Cre coding sequence is followed by an internal ribosomal entry site and sequence encoding green fluorescent protein (GFP). At embryonic day (E) 10.5, embryos bearing both this transgene and a lacZ- expressing Cre reporter exhibit beta-galactosidase activity/immunoreactivity in the intersomitic vessels, endocardium, aorta, fetal liver, yolk sac, and umbilical and vitelline arteries. In the E11.5-E12.5 placenta, activity is observed in the umbilical artery and primarily in the large vessels, rather than the labyrinth, of the chorionic plate.
(J:198989)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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Cdh5
(mouse)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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| Original: |
J:198989 Oberlin E, et al., Definitive human and mouse hematopoiesis originates from the embryonic endothelium: a new class of HSCs based on VE-cadherin expression. Int J Dev Biol. 2010;54(6-7):1165-73 |
| All: |
2 reference(s) |
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Analysis Tools
