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Hsd11b2tm1.1(cre/GFP)Rpa
Targeted Allele Detail
Summary
Symbol: Hsd11b2tm1.1(cre/GFP)Rpa
Name: hydroxysteroid 11-beta dehydrogenase 2; targeted mutation 1.1, Richard D Palmiter
MGI ID: MGI:5896324
Synonyms: Hsd11b2Cre, Hsd11b2Cre:GFP
Gene: Hsd11b2  Location: Chr8:106245387-106250620 bp, + strand  Genetic Position: Chr8, 53.04 cM
Alliance: Hsd11b2tm1.1(cre/GFP)Rpa page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:239846
Parent Cell Line:  G4 (ES Cell)
Strain of Origin:  (129S6/SvEvTac x C57BL/6NCrl)F1
Mutation
description
Allele Type:    Targeted (Recombinase, Reporter)
Mutation:    Insertion
 
Hsd11b2tm1.1(cre/GFP)Rpa expression driven by 1 gene
 
Mutation details: IRES-Myc tag-nuclear localization signal (NLS)-cre-GFP-frt-neomycin-frt were introduced just after the termination codon of the mouse Hsd11b2 gene via homologous recombination. The neomycin cassette was excised through crosses with animals broadly expressing Flp recombinase. (J:239846)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Hsd11b2 (mouse)
Summary of all recombinase alleles driven by Hsd11b2.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hsd11b2 Mutation:  19 strains or lines available
References
Original:  J:239846 Jarvie BC, et al., HSD2 neurons in the hindbrain drive sodium appetite. Nat Neurosci. 2017 Feb;20(2):167-169
All:  3 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
09/03/2024
MGI 6.24 		The Jackson Laboratory