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Gcgtm1.1(cre/ERT2)Gkg
Targeted Allele Detail
Summary
Symbol: Gcgtm1.1(cre/ERT2)Gkg
Name: glucagon; targeted mutation 1.1, George K Gittes
MGI ID: MGI:5898440
Synonyms: GcgCreER2, Gcgtm1(cre/ERT2)Cshi
Gene: Gcg  Location: Chr2:62304874-62313994 bp, - strand  Genetic Position: Chr2, 35.85 cM
Alliance: Gcgtm1.1(cre/ERT2)Gkg page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:256199
Parent Cell Line:  G4 (ES Cell)
Strain of Origin:  (129S6/SvEvTac x C57BL/6NCrl)F1
Mutation
description
Allele Type:    Targeted (Inducible, Null/knockout, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Gcgtm1.1(cre/ERT2)Gkg expression driven by 1 gene
 
Mutation details: The targeting construct is designed to insert a creERT2 fusion gene (a Cre recombinase fused to a human estrogen receptor ligand binding domain) followed by an SV40 polyadenylation signal, and a FRT-flanked neomycin resistance (neo) cassette into exon 2 of the gene. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:256199)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Gcg (mouse)
Summary of all recombinase alleles driven by Gcg.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gcg Mutation:  34 strains or lines available
References
Original:  J:256199 Shiota C, et al., Gcg (CreERT2) knockin mice as a tool for genetic manipulation in pancreatic alpha cells. Diabetologia. 2017 Dec;60(12):2399-2408
All:  6 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory