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Tg(Nphs1-cre)10Mska
Transgene Detail
Summary
Symbol: Tg(Nphs1-cre)10Mska
Name: transgene insertion 10, Taiji Matsusaka
MGI ID: MGI:5902390
Synonyms: Nephrin-Cre
Transgene: Tg(Nphs1-cre)10Mska  Location: unknown  
Alliance: Tg(Nphs1-cre)10Mska page
Transgene
origin
Strain of Origin:  (C57BL/6 x DBA/2)F1 x C57BL/6N
Transgene
description
Transgene Type:    Transgenic (Recombinase)
Mutation:    Insertion
 
Tg(Nphs1-cre)10Mska expression driven by 1 gene
 
Mutation details: The cre recombinase cDNA was combined with a 5.5kb mouse Nphs1 promoter fragment and intron of the rabbit beta-globin gene. The construct was injected into fertilized eggs from (C57BL/6 x DBA/2) x C57BL/6N mice. Cre mRNA was detected in the kidney by Northern blot in five lines, and Cre protein was detected in podocytes by immunohistochemistry in four lines. Line 10 was established by backcrossing to C57BL/6 mice. (J:126591)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Nphs1 (mouse)
Summary of all recombinase alleles driven by Nphs1.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:126591 Asano T, et al., Permanent genetic tagging of podocytes: fate of injured podocytes in a mouse model of glomerular sclerosis. J Am Soc Nephrol. 2005 Aug;16(8):2257-62
All:  5 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory