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Slc12a3em1(cre/ERT2)Amc
Endonuclease-mediated Allele Detail
Summary
Symbol: Slc12a3em1(cre/ERT2)Amc
Name: solute carrier family 12, member 3; endonuclease-mediated mutation 1, Andrew P McMahon
MGI ID: MGI:5902998
Synonyms: Slc12a3-IRES-CRE-ERT2
Gene: Slc12a3  Location: Chr8:95055829-95092842 bp, + strand  Genetic Position: Chr8, 46.46 cM
Alliance: Slc12a3em1(cre/ERT2)Amc page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:159099
Parent Cell Line:  JM8.N4 (ES Cell)
Strain of Origin:  C57BL/6N
Mutation
description
Allele Type:    Endonuclease-mediated (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Slc12a3em1(cre/ERT2)Amc expression driven by 1 gene
 
Mutation details: Plasmids encoding a signal guide RNA designed to introduce a cre/ERT2 knock-in mutation into 3' UTR near the stop codon of the Slc12a3 gene and the cas9 nuclease were introduced into the cytoplasm of C57BL/6N-derived JM8.N4 ES cells. (J:159099, J:354771)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Slc12a3 (mouse)
Summary of all recombinase alleles driven by Slc12a3.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Slc12a3 Mutation:  54 strains or lines available
References
Original:  J:159099 McMahon A, et al., Summary of mouse strains characterized by GUDMAP consortium. Unpublished. 2010;
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory