Il22tm1.1(cre)Lky
Targeted Allele Detail
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| Symbol: |
Il22tm1.1(cre)Lky |
| Name: |
interleukin 22; targeted mutation 1.1, Richard M Locksley |
| MGI ID: |
MGI:5906262 |
| Gene: |
Il22 Location: Chr10:118040847-118045952 bp, + strand Genetic Position: Chr10, 66.67 cM
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| Alliance: |
Il22tm1.1(cre)Lky page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:242759
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| Parent Cell Line: |
PRX-B6T (ES Cell)
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| Strain of Origin: |
C57BL/6J
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| Allele Type: |
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Targeted (Null/knockout, Recombinase, Reporter) |
| Mutation: |
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Insertion
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Il22tm1.1(cre)Lky expression driven by
1 gene
Knock-in expression driven by:
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Mutation details: Rabbit beta-globin (partial exon 2-3 genomic sequence serving as an artificial intron and splicing donor/acceptor), tandem dimer red fluorescent protein (tdTomato), encephalomyocarditis virus (EMCV) internal ribosome entry site (IRES), huCre (P1 phage cre-recombinase cDNA optimized for human/mammalian cells), bovine growth hormone (bGH) poly-adenylation signal (pA), and a loxP-flanked neomycin cassette were introduced to exon 1 of the mouse Il22 gene via homologous recombination in embryonic stem (ES) cells. The floxed neomycin cassette was excised by through crosses with CMV-cre mice. Mice express tdTomato fluorescent reporter and cre in cells where Il22 is expressed.
(J:242759)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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Il22
(mouse)
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| Original: |
J:242759 Savage AK, et al., The Development of Steady-State Activation Hubs between Adult LTi ILC3s and Primed Macrophages in Small Intestine. J Immunol. 2017 Sep 1;199(5):1912-1922 |
| All: |
1 reference(s) |
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Analysis Tools
