Mir218-1<em1Slp> Endonuclease-mediated Allele Detail MGI Mouse (MGI:5906822)

Mir218-1^em1Slp
Endonuclease-mediated Allele Detail

Summary

Symbol:	Mir218-1^em1Slp
Name:	microRNA 218-1; endonuclease-mediated mutation 1, Samuel L Pfaff
MGI ID:	MGI:5906822
Gene:	Mir218-1 Location: Chr5:48381284-48381393 bp, + strand Genetic Position: Chr5, 26.17 cM
Alliance:	Mir218-1^em1Slp page

Mutation
origin

Strain of Origin:

Not Specified

Mutation
description

Allele Type:		Endonuclease-mediated (Null/knockout)
Mutation:		Intragenic deletion
		Mutation details: A 359bp deletion encompassing the microRNA was created using CRISPR/Cas9. Expression of Mir218 is reduced in single homozygotes and eliminated in mice homozygous for both this allele and Mir218-2^em1Slp (J:227113)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Mir218-1 Mutation:	0 strains or lines available

References

Original:	J:227113 Amin ND, et al., Loss of motoneuron-specific microRNA-218 causes systemic neuromuscular failure. Science. 2015 Dec 18;350(6267):1525-9
All:	3 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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