Mir218-1<em1Slp> Endonuclease-mediated Allele Detail MGI Mouse (MGI:5906822)

Mir218-1^em1Slp
Endonuclease-mediated Allele Detail

Summary

Symbol:	Mir218-1^em1Slp
Name:	microRNA 218-1; endonuclease-mediated mutation 1, Samuel L Pfaff
MGI ID:	MGI:5906822
Gene:	Mir218-1 Location: Chr5:48381284-48381393 bp, + strand Genetic Position: Chr5, 26.17 cM
Alliance:	Mir218-1^em1Slp page

Mutation
origin

Strain of Origin:

Not Specified

Mutation
description

Allele Type:		Endonuclease-mediated (Null/knockout)
Mutation:		Intragenic deletion
		Mutation details: A 359bp deletion encompassing the microRNA was created using CRISPR/Cas9. Expression of Mir218 is reduced in single homozygotes and eliminated in mice homozygous for both this allele and Mir218-2^em1Slp (J:227113)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Mir218-1 Mutation:	0 strains or lines available

References

Original:	J:227113 Amin ND, et al., Loss of motoneuron-specific microRNA-218 causes systemic neuromuscular failure. Science. 2015 Dec 18;350(6267):1525-9
All:	3 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24