Krt14<tm1.1(cre/ERT2)Hjg> Targeted Allele Detail MGI Mouse (MGI:5908393)

Krt14^{tm1.1(cre/ERT2)Hjg}
Targeted Allele Detail

Summary

Symbol:	Krt14^{tm1.1(cre/ERT2)Hjg}
Name:	keratin 14; targeted mutation 1.1, Hermann-Josef Grone
MGI ID:	MGI:5908393
Synonyms:	K14CreERT2, Krt14^{tm1.1(cre/ERT2)Dkfz}
Gene:	Krt14 Location: Chr11:100093988-100098336 bp, - strand Genetic Position: Chr11, 63.43 cM, cytoband D
Alliance:	Krt14^{tm1.1(cre/ERT2)Hjg} page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:201085
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Mutation
description

Allele Type:

Targeted (Inducible, Recombinase)

Inducer:

tamoxifen

Mutation:

Insertion

Krt14^{tm1.1(cre/ERT2)Hjg} expression driven by 1 gene

Mutation details: An icre/ERT2 cassette followed by an Frt-flanked neo selection cassette was inserted into downstream of ATG-start codon in frame by homologous recombination in ES cells. Correctly targeted ES cell clones were injected into C57BL/6 blastocyts. Mice were crossed to Flp-expressing mice to delete the neo cassette. (J:201085)

Recombinase
activity

Activity:	Tissue activity of this recombinase allele
Driver:	Krt14 (mouse) Summary of all recombinase alleles driven by Krt14. Comparative matrix view of recombinase activities Alliance mouse Krt14 gene page

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available Cell Lines: 0 lines available
Carrying any Krt14 Mutation:	38 strains or lines available

References

Original:	J:201085 Amen N, et al., Differentiation of epidermal keratinocytes is dependent on glucosylceramide:ceramide processing. Hum Mol Genet. 2013 Oct 15;22(20):4164-79
All:	1 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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