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Mslntm1.1(cre/ERT2)Ilw
Targeted Allele Detail
Summary
Symbol: Mslntm1.1(cre/ERT2)Ilw
Name: mesothelin; targeted mutation 1.1, Irving L Weissman
MGI ID: MGI:5910114
Synonyms: MslnCLN, MslnnLacZ-ER-Cre
Gene: Msln  Location: Chr17:25967587-25973352 bp, - strand  Genetic Position: Chr17, 12.85 cM, cytoband A3.3
Alliance: Mslntm1.1(cre/ERT2)Ilw page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:195251
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Inducible, Null/knockout, Recombinase, Reporter)
Inducer:    tamoxifen
Mutations:    Insertion, Intragenic deletion
 
Mslntm1.1(cre/ERT2)Ilw expression driven by 1 gene
 
Mutation detailsThe ATG start codon of Msln gene was replaced by the CreERT2-IRES-lacZ-polyA signal and FRT-flanked PGKneo cassetter in exon 1. CThe neo cassette was laater removed by crossing with Flpe-expressing mice. (J:195251)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Msln (mouse)
Summary of all recombinase alleles driven by Msln.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Msln Mutation:  38 strains or lines available
References
Original:  J:195251 Rinkevich Y, et al., Identification and prospective isolation of a mesothelial precursor lineage giving rise to smooth muscle cells and fibroblasts for mammalian internal organs, and their vasculature. Nat Cell Biol. 2012 Dec;14(12):1251-60
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory