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Foxc2tm1.1(cre/ERT2)Aot
Targeted Allele Detail
Summary
Symbol: Foxc2tm1.1(cre/ERT2)Aot
Name: forkhead box C2; targeted mutation 1.1, Kazushi Aoto
MGI ID: MGI:5910136
Synonyms: Foxc2CreERTT2
Gene: Foxc2  Location: Chr8:121842910-121845634 bp, + strand  Genetic Position: Chr8, 70.33 cM
Alliance: Foxc2tm1.1(cre/ERT2)Aot page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:237938
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Foxc2tm1.1(cre/ERT2)Aot expression driven by 1 gene
 
Mutation details: A CreERT2 cassette was inserted downstream of the initiation codon of Foxc2 gene, followed by an Frtflanked PGK-neo sequence via homologouse recombination in embryonic stem (ES) cells. Correctly targeted ES cells were injected into host blastocysts to produce germline chimeric males. Chimeric mice were crossed with Act-FLPe mice to remove the PGK-neo selection cassette. (J:237938)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Foxc2 (mouse)
Summary of all recombinase alleles driven by Foxc2.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Foxc2 Mutation:  15 strains or lines available
References
Original:  J:237938 Amin MB, et al., Foxc2CreERT2 knock-in mice mark stage-specific Foxc2-expressing cells during mouse organogenesis. Congenit Anom (Kyoto). 2017 Jan;57(1):24-31
All:  3 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory