Ctsctm1Ike
Targeted Allele Detail
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| Symbol: |
Ctsctm1Ike |
| Name: |
cathepsin C; targeted mutation 1, Kazuhiro Ikenaka |
| MGI ID: |
MGI:5910745 |
| Synonyms: |
CatCKD, CatCSTOP-tetO |
| Gene: |
Ctsc Location: Chr7:87927293-87960096 bp, + strand Genetic Position: Chr7, 49.11 cM, cytoband D3-E1.1
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| Alliance: |
Ctsctm1Ike page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:242069
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| Parent Cell Line: |
RENKA (ES Cell)
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| Strain of Origin: |
C57BL/6N
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| Allele Type: |
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Targeted (Conditional ready, Null/knockout) |
| Mutation: |
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Insertion
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Mutation details: A Neo STOP-tetO cassette was inserted just upstream of the translation initiation site. The cassette contains the following elements: a loxP site, an FRT site, a neomycin resistance gene cassette, a transcription and translation STOP cassette, an FRT site, a tetO cassette (the tetracycline operon site and a CMV minimal promoter) and a loxP site. In the absence of tetracycline transactivator (tTA) activity this allele is a null allele. The gene can be activated by expressing tTA (by crossing with a tTA transgenic mouse) in the absence of tetracycline family antibiotics.
(J:242069)
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| Original: |
J:242069 Shimizu T, et al., The balance between cathepsin C and cystatin F controls remyelination in the brain of Plp1-overexpressing mouse, a chronic demyelinating disease model. Glia. 2017 Jun;65(6):917-930 |
| All: |
3 reference(s) |
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Analysis Tools
