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Oprk1tm1.1(cre)Sros
Targeted Allele Detail
Summary
Symbol: Oprk1tm1.1(cre)Sros
Name: opioid receptor, kappa 1; targeted mutation 1.1, Sarah Ross
MGI ID: MGI:5910988
Synonyms: KOR-Cre
Gene: Oprk1  Location: Chr1:5658689-5676354 bp, + strand  Genetic Position: Chr1, 1.89 cM, cytoband A2-A3
Alliance: Oprk1tm1.1(cre)Sros page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:229097
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutations:    Insertion, Intragenic deletion
 
Oprk1tm1.1(cre)Sros expression driven by 1 gene
 
Mutation details: The coding region of the gene in exon 2 was replaced with a Cre recombinase gene followed by a polyadenylation sequence. An Frt-flanked neomycin selection cassette was inserted at the 3' end, but removed by flp-mediated recmobination in the final allele. (J:229097)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Oprk1 (mouse)
Summary of all recombinase alleles driven by Oprk1.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Oprk1 Mutation:  30 strains or lines available
References
Original:  J:229097 Cai X, et al., Generation of a KOR-Cre knockin mouse strain to study cells involved in kappa opioid signaling. Genesis. 2016 Jan;54(1):29-37
All:  5 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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11/12/2024
MGI 6.24 		The Jackson Laboratory