Tg(ACTB-Wld)4858Cole
Transgene Detail
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Symbol: |
Tg(ACTB-Wld)4858Cole |
Name: |
transgene insertion 4858, Michael Coleman |
MGI ID: |
MGI:5911101 |
Transgene: |
Tg(ACTB-Wld)4858Cole Location: unknown
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Alliance: |
Tg(ACTB-Wld)4858Cole page
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Transgene Type: |
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Transgenic (Inserted expressed sequence) |
Mutation: |
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Undefined
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Tg(ACTB-Wld)4858Cole expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Note |
mouse |
Wld (MGI:98952) |
expresses Wlds fusion gene |
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Mutation details: A construct consisting of the human beta actin promoter followed by the cDNA for Wlds that is an in-frame fusion of exon 1 and 2 of Ube4b to exon 2 onwards of Nmnat1, was injected into the pronuclei of fertilized (C57BL/6 x CBA)F1 eggs that do not express Wlds. Expression level of this transgene is lower than that of Wlds in the C57Bl/6Ola strain.
(J:72936)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Original: |
J:72936 Mack TG, et al., Wallerian degeneration of injured axons and synapses is delayed by a Ube4b/Nmnat chimeric gene. Nat Neurosci. 2001 Dec;4(12):1199-206 |
All: |
1 reference(s) |
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