Agrptm1(cre*)Rpa
Targeted Allele Detail
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| Symbol: |
Agrptm1(cre*)Rpa |
| Name: |
agouti related neuropeptide; targeted mutation 1, Richard D Palmiter |
| MGI ID: |
MGI:5911621 |
| Synonyms: |
AgrpnsCre |
| Gene: |
Agrp Location: Chr8:106293327-106306477 bp, - strand Genetic Position: Chr8, 53.04 cM, cytoband D1-D2
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| Alliance: |
Agrptm1(cre*)Rpa page
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| Allele Type: |
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Targeted (Inducible, Recombinase) |
| Inducer: |
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aminoglycosides |
| Mutation: |
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Insertion
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Agrptm1(cre*)Rpa expression driven by
1 gene
Knock-in expression driven by:
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Mutation details: A cassette containing a nuclear localization signal, a mutated cre gene (nsCre) in which an in-frame nonsense mutation (TGA) was introduced into the position 837 of the coding region of the wild-type Cre recombinase gene, followed by frt-flanked neo gene was inserted just 5' of the initiation codon of the Agrp gene. Mutant mRNAs transcribed from nsCre transgene can be efficiently translated into full-length, functional Cre recombinase in the presence of nonsense suppressors such as aminoglycosides or synthetic homologs.
(J:232044)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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Agrp
(mouse)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Agrp Mutation: |
17 strains or lines available
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| Original: |
J:232044 Meng F, et al., New inducible genetic method reveals critical roles of GABA in the control of feeding and metabolism. Proc Natl Acad Sci U S A. 2016 Mar 29;113(13):3645-50 |
| All: |
1 reference(s) |
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Analysis Tools
