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Tac2tm1.1(cre)Mgmj
Targeted Allele Detail
Summary
Symbol: Tac2tm1.1(cre)Mgmj
Name: tachykinin 2; targeted mutation 1.1, Martin G Myers, Jr
MGI ID: MGI:5911624
Synonyms: Tac2cre
Gene: Tac2  Location: Chr10:127560347-127567637 bp, + strand  Genetic Position: Chr10, 74.81 cM, cytoband D3
Alliance: Tac2tm1.1(cre)Mgmj page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:234023
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Tac2tm1.1(cre)Mgmj expression driven by 1 gene
 
Mutation details: An Frt-neo-Frt-IRES-cre cassette was inserted between the stop codon and polyA site of the Tac2 gene by homologous recombination in R1 ES cells. Correctly targeted ES cells were injected into C57BL/6 blastocysts. The resulting chimeric animals were crossed to C57BL/6J mice, and then bred to a line expressing Flp recombinase to remove the Frt-flanked neo cassette. (J:234023)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Tac2 (mouse)
Summary of all recombinase alleles driven by Tac2.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tac2 Mutation:  18 strains or lines available
References
Original:  J:234023 Greenwald-Yarnell ML, et al., ERalpha in Tac2 Neurons Regulates Puberty Onset in Female Mice. Endocrinology. 2016 Apr;157(4):1555-65
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory