Tg(Sst-mCherry,-icre)#Fmgb
Transgene Detail
|
|
| Symbol: |
Tg(Sst-mCherry,-icre)#Fmgb |
| Name: |
transgene insertion, Fiona M Gribble |
| MGI ID: |
MGI:5911682 |
| Synonyms: |
SST-Cre |
| Transgene: |
Tg(Sst-mCherry,-icre)#Fmgb Location: unknown
|
| Alliance: |
Tg(Sst-mCherry,-icre)#Fmgb page
|
|
| Germline Transmission: |
Earliest citation of germline transmission:
J:239793
|
| Parent Cell Line: |
ATOM1 (ES Cell)
|
| Strain of Origin: |
(C57BL/6 x 129)F1
|
|
| Transgene Type: |
|
Transgenic (Recombinase) |
| Mutation: |
|
Insertion
|
| |
|
Tg(Sst-mCherry,-icre)#Fmgb expression driven by
1 gene
Transgene expression driven by:
| Organism |
Driver Gene |
Note |
| mouse |
Sst (MGI:98326) |
|
|
| |
|
Mutation details: A sequences coding for mCherry and improved cre recombinase gene (icre) separated by a viral T2A-sequence to allow bicistronic expression replaced the coding sequence between the start codon in exon 1 and the stop codon in exon 2 in the murine based bacterial artificial chromosome (BAC bQ73b10). Initially 4 founders (SST-Cre33, -38, -43 and -44) were generated, of which SST-Cre-43 failed to pass on the transgene. Subsequencty, two strains (SST-Cre33 and -38) lost this positive
reporter expression. The pound symbol (#) is used when no line is specified and/or lines are pooled.
(J:239793)
|
|
|
|
Activity: |
 Tissue activity of this recombinase allele
|
|
Driver:
|
Sst
(mouse)
|
| |
|
|
| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
|
| Original: |
J:239793 Adriaenssens A, et al., A Transcriptome-Led Exploration of Molecular Mechanisms Regulating Somatostatin-Producing D-Cells in the Gastric Epithelium. Endocrinology. 2015 Nov;156(11):3924-36 |
| All: |
2 reference(s) |
|
Analysis Tools
