Tg(Sst-mCherry,-icre)44Fmgb
Transgene Detail
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| Symbol: |
Tg(Sst-mCherry,-icre)44Fmgb |
| Name: |
transgene insertion 44, Fiona M Gribble |
| MGI ID: |
MGI:5911684 |
| Synonyms: |
Somatostatin-Cre, SST-Cre44 |
| Transgene: |
Tg(Sst-mCherry,-icre)44Fmgb Location: unknown
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| Alliance: |
Tg(Sst-mCherry,-icre)44Fmgb page
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| Strain of Origin: |
Not Specified
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| Transgene Type: |
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Transgenic (Recombinase) |
| Mutation: |
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Insertion
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Tg(Sst-mCherry,-icre)44Fmgb expression driven by
1 gene
Transgene expression driven by:
| Organism |
Driver Gene |
Note |
| mouse |
Sst (MGI:98326) |
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Mutation details: A sequences coding for mCherry and improved cre recombinase gene (icre) separated by a viral T2A-sequence to allow bicistronic expression replaced the coding sequence between the start codon in exon 1 and the stop codon in exon 2 in the murine based bacterial artificial chromosome (BAC bQ73b10). Initially 4 founders (SST-Cre33, -38, -43 and -44) were generated, of which SST-Cre-43 failed to pass on the transgene. Subsequencty, two strains (SST-Cre33 and -38) lost this positive
reporter expression. Only the remaining strain SST-Cre-44 was eventually crossed back into a C57B6 background for eight generations.
(J:239793)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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Sst
(mouse)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:239793 Adriaenssens A, et al., A Transcriptome-Led Exploration of Molecular Mechanisms Regulating Somatostatin-Producing D-Cells in the Gastric Epithelium. Endocrinology. 2015 Nov;156(11):3924-36 |
| All: |
6 reference(s) |
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Analysis Tools
