Il9tm1.1(icre)Lky
Targeted Allele Detail
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| Symbol: |
Il9tm1.1(icre)Lky |
| Name: |
interleukin 9; targeted mutation 1.1, Richard M Locksley |
| MGI ID: |
MGI:5927676 |
| Synonyms: |
IL99er |
| Gene: |
Il9 Location: Chr13:56627090-56630059 bp, - strand Genetic Position: Chr13, 30.06 cM
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| Alliance: |
Il9tm1.1(icre)Lky page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:247962
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| Parent Cell Line: |
PRX-B6T (ES Cell)
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| Strain of Origin: |
C57BL/6J
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| Allele Type: |
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Targeted (Null/knockout, Recombinase, Reporter) |
| Mutations: |
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Insertion, Intragenic deletion
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Il9tm1.1(icre)Lky expression driven by
1 gene
Knock-in expression driven by:
| Organism |
Driver Gene |
Note |
| mouse |
Il9 (MGI:96563) |
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Mutation details: A composite fluorescent reporter/recombinase cassette was introduced to exon 1 of the gene. The targeting vector incorporated rabbit beta-globin (exon 2-3 partial genomic sequence serving as an artificial intron and splicing donor/acceptor), EYFP fluorescent reporter, encephalomyocarditic virus (EMCV) internal ribosome entry site (IRES), P1 phage cre recombinase cDNA optimized for mammalian cells (hCre; iCre), bovine growth hormone (bGH) poly-adenylation signal (pA), and a floxed neomycin resistance cassette. Cre-mediated recombination removed the floxed neo cassette.
(J:247962)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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Il9
(mouse)
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| Original: |
J:247962 Mohapatra A, et al., Group 2 innate lymphoid cells utilize the IRF4-IL-9 module to coordinate epithelial cell maintenance of lung homeostasis. Mucosal Immunol. 2016 Jan;9(1):275-86 |
| All: |
1 reference(s) |
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Analysis Tools
