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Gene Expression Data
Assay Details
Assay
Reference: J:193285 Momb J, et al., Deletion of Mthfd1l causes embryonic lethality and neural tube and craniofacial defects in mice. Proc Natl Acad Sci U S A. 2013 Jan 8;110(2):549-54
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:6093715
Gene symbol: Mthfd1l
Gene name: methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
Reporter: lacZ
Direct Detection
Results
Specimen 3D/E: embryonic day 12.5; Mthfd1ltm1b(EUCOMM)Wtsi/Mthfd1ltm1b(EUCOMM)Wtsi (more )
Structure Level Pattern Image Note
TS20: central nervous system Present 3E , 3D Neural tube.
Specimen 3G: embryonic day 12.5; Mthfd1ltm1b(EUCOMM)Wtsi/Mthfd1ltm1b(EUCOMM)Wtsi (more )
Structure Level Pattern Image Note
TS20: head Present 3G
Specimen 4A: embryonic day 10.5; Mthfd1ltm1b(EUCOMM)Wtsi/Mthfd1l+ (more )
Note: 37 somites
Structure Level Pattern Image Note
TS17: eye Present 4A
TS17: heart Present 4A
TS17: limb Present 4A
TS17: trunk Present Regionally restricted 4A Expressed in the dorsal midline region.
Specimen 4B: embryonic day 10.5; Mthfd1ltm1b(EUCOMM)Wtsi/Mthfd1ltm1b(EUCOMM)Wtsi (more )
Note: 34 somites, littermate of embryos in 4A.
Structure Level Pattern Image Note
TS17: embryo Present Ubiquitous 4B Superficially ubiquitous.
Specimen 4D/G: embryonic day 10.5; Mthfd1ltm1b(EUCOMM)Wtsi/Mthfd1l+ (more )
Structure Level Pattern Image Note
TS17: neural tube Present Regionally restricted 4D , 4G Expressed in the basal surface of the dorsal neuroepithelium. Rarely detected in cells within and outside of the neural tube.
Specimen 4E/H: embryonic day 10.5; Mthfd1ltm1b(EUCOMM)Wtsi/Mthfd1ltm1b(EUCOMM)Wtsi (more )
Structure Level Pattern Image Note
TS17: neural tube Strong 4H , 4E Expressed in the neuroepithelium; however, expression is less restricted dorsally.
TS17: embryo Strong Ubiquitous 4H , 4E
Specimen 4J: embryonic day 11.5; Mthfd1ltm1b(EUCOMM)Wtsi/Mthfd1l+ (more )
Note: 44 somites
Structure Level Pattern Image Note
TS19: eye Present 4J
TS19: heart Present 4J
TS19: limb Present 4J
TS19: trunk Present Regionally restricted 4J Expressed in the dorsal midline region.
Specimen 4K: embryonic day 11.5; Mthfd1ltm1b(EUCOMM)Wtsi/Mthfd1ltm1b(EUCOMM)Wtsi (more )
Note: 42 somites, littermates of embryos in 4J.
Structure Level Pattern Image Note
TS19: embryo Present Ubiquitous 4K Superficially ubiquitous.
Specimen 4L/N: embryonic day 11.5; Mthfd1ltm1b(EUCOMM)Wtsi/Mthfd1l+ (more )
Structure Level Pattern Image Note
TS19: neural tube Present Regionally restricted 4N , 4L Expressed in the basal surface of the dorsal neuroepithelium. Rarely detected in cells within and outside of the neural tube.
Specimen 4M/O: embryonic day 11.5; Mthfd1ltm1b(EUCOMM)Wtsi/Mthfd1ltm1b(EUCOMM)Wtsi (more )
Structure Level Pattern Image Note
TS19: neural tube Strong 4O , 4M Expressed in the neuroepithelium; however, expression is less restricted dorsally.
TS19: embryo Strong Ubiquitous 4M , 4O
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
06/12/2024
MGI 6.13 		The Jackson Laboratory