Tg(TLR4*D299G*T399I)1Haj
Transgene Detail
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| Symbol: |
Tg(TLR4*D299G*T399I)1Haj |
| Name: |
transgene insertion 1, Adeline M Hajjar |
| MGI ID: |
MGI:6094858 |
| Transgene: |
Tg(TLR4*D299G*T399I)1Haj Location: unknown
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| Alliance: |
Tg(TLR4*D299G*T399I)1Haj page
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| Transgene Type: |
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Transgenic (Humanized sequence, Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(TLR4*D299G*T399I)1Haj expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
TLR4 (7099) |
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Mutated human gene resulting in Asp299Gly and Thr399Ile substitutions |
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Mutation details: The transgene was generated with a modified version of human genomic BAC RP11-150L1. Using recombineering, A>G and C>T substitutions were introduced that resulted in D299G (p.Asp299Gly) and T399I (p.Thr399Ile) mutations in the translated petide, respectively. The copy number of this allele, as determined by RT-PCR, is 1.
(J:248428)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:248428 Hajjar AM, et al., Expression level of human TLR4 rather than sequence is the key determinant of LPS responsiveness. PLoS One. 2017;12(10):e0186308 |
| All: |
1 reference(s) |
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Analysis Tools
