Myh10<ehc> Chemically induced Allele Detail MGI Mouse (MGI:6108305)

Myh10^ehc
Chemically induced Allele Detail

Summary

Symbol:	Myh10^ehc
Name:	myosin, heavy polypeptide 10, non-muscle; embryonic hydrocephalus and cardiac defects
MGI ID:	MGI:6108305
Synonyms:	Myh10^l11Jus27.1
Gene:	Myh10 Location: Chr11:68582385-68707458 bp, + strand Genetic Position: Chr11, 41.95 cM, cytoband B3
Alliance:	Myh10^ehc page

Mutation
origin

Strain of Origin:

C57BL/6J

Mutation
description

Allele Type:		Chemically induced (ENU) (Null/knockout)
Mutation:		Single point mutation
		Mutation details: ENU mutagenesis induced a G to T in the splice donor site following exon 18 that results in skipping of the exon and protein truncation (1-703). THe predicted truncated protein lacks the coiled coil rod domain and undetectable on western blots with the C-terminal NMHC IIB antibody. (J:248868)
Inheritance:		Recessive

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Myh10 Mutation:	95 strains or lines available

Notes

This mutation was one of two identified in l11Jus27.

References

Original:	J:248868 Ridge LA, et al., Non-muscle myosin IIB (Myh10) is required for epicardial function and coronary vessel formation during mammalian development. PLoS Genet. 2017 Oct;13(10):e1007068
All:	1 reference(s)

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