Myh10<ehc> Chemically induced Allele Detail MGI Mouse (MGI:6108305)

Myh10^ehc
Chemically induced Allele Detail

Summary

Symbol:	Myh10^ehc
Name:	myosin, heavy polypeptide 10, non-muscle; embryonic hydrocephalus and cardiac defects
MGI ID:	MGI:6108305
Synonyms:	Myh10^l11Jus27.1
Gene:	Myh10 Location: Chr11:68582385-68707458 bp, + strand Genetic Position: Chr11, 41.95 cM, cytoband B3
Alliance:	Myh10^ehc page

Mutation
origin

Strain of Origin:

C57BL/6J

Mutation
description

Allele Type:		Chemically induced (ENU) (Null/knockout)
Mutation:		Single point mutation
		Mutation details: ENU mutagenesis induced a G to T in the splice donor site following exon 18 that results in skipping of the exon and protein truncation (1-703). THe predicted truncated protein lacks the coiled coil rod domain and undetectable on western blots with the C-terminal NMHC IIB antibody. (J:248868)
Inheritance:		Recessive

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Myh10 Mutation:	95 strains or lines available

Notes

This mutation was one of two identified in l11Jus27.

References

Original:	J:248868 Ridge LA, et al., Non-muscle myosin IIB (Myh10) is required for epicardial function and coronary vessel formation during mammalian development. PLoS Genet. 2017 Oct;13(10):e1007068
All:	1 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24