Cc2d1atm1c(KOMP)Wtsi
Targeted Allele Detail
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| Symbol: |
Cc2d1atm1c(KOMP)Wtsi |
| Name: |
coiled-coil and C2 domain containing 1A; targeted mutation 1c, Wellcome Trust Sanger Institute |
| MGI ID: |
MGI:6111286 |
| Synonyms: |
Cc2d1aflx, Freud-1flx |
| Gene: |
Cc2d1a Location: Chr8:84859457-84874546 bp, - strand Genetic Position: Chr8, 40.32 cM
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| Alliance: |
Cc2d1atm1c(KOMP)Wtsi page
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| IMPC: |
Cc2d1a gene page |
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| Germline Transmission: |
Earliest citation of germline transmission:
J:241103
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| Parent Cell Line: |
JM8.N4 (ES Cell)
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| Strain of Origin: |
C57BL/6N
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| Project Collection: |
KOMP-CSD
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| Allele Type: |
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Targeted (Conditional ready) |
| Mutation: |
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Insertion
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Mutation details: The L1L2_Bact_P cassette was inserted at position 84864826 of Chromosome 8 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 84866480. The critical exon(s) is/are thus flanked by loxP sites.A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele to remove the lacZ sequence and neo selection cassette, leaving loxP sites flanking the critical exon(s).
(J:241103)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Cc2d1a Mutation: |
32 strains or lines available
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| Original: |
J:241103 Oaks AW, et al., Cc2d1a Loss of Function Disrupts Functional and Morphological Development in Forebrain Neurons Leading to Cognitive and Social Deficits. Cereb Cortex. 2017 Feb 01;27(2):1670-1685 |
| All: |
6 reference(s) |
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Analysis Tools
