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Cdk20tm1.1Jegg
Targeted Allele Detail
Summary
Symbol: Cdk20tm1.1Jegg
Name: cyclin dependent kinase 20; targeted mutation 1.1, Jonathan Eggenschwiler
MGI ID: MGI:6113512
Gene: Cdk20  Location: Chr13:64580133-64587536 bp, + strand  Genetic Position: Chr13, 33.26 cM
Alliance: Cdk20tm1.1Jegg page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:243907
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt1b-m2
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: A loxP site was inserted upstream of exon 1 and a floxed neo cassette was inserted downstream of exon 2 via homologous recombination. Cre mediated recombination deleted exons 1, 2 and the neo cassette. Western blot analysis confirmed the absenceof protein expression in homozygous null embryos. (J:243907)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 82 assay results
In Structures Affected by this Mutation: 9 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cdk20 Mutation:  10 strains or lines available
References
Original:  J:243907 Snouffer A, et al., Cell Cycle-Related Kinase (CCRK) regulates ciliogenesis and Hedgehog signaling in mice. PLoS Genet. 2017 Aug;13(8):e1006912
All:  3 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory