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Lyz2tm1(cre/ERT2)Grtn
Targeted Allele Detail
Summary
Symbol: Lyz2tm1(cre/ERT2)Grtn
Name: lysozyme 2; targeted mutation 1, Florian R Greten
MGI ID: MGI:6114757
Synonyms: LysM-Cre ERT2
Gene: Lyz2  Location: Chr10:117113446-117118177 bp, - strand  Genetic Position: Chr10, 65.34 cM
Alliance: Lyz2tm1(cre/ERT2)Grtn page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:252269
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutations:    Insertion, Intragenic deletion
 
Lyz2tm1(cre/ERT2)Grtn expression driven by 1 gene
 
Mutation details: A targeting construct was generated by replacing Exon 1 of Lyz2 gene with a cre/ERT2, and an FRT-flanked neomycin/kanamycin cassette to drive inducible recombinase activity in myeloid cells. (J:252269)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Lyz2 (mouse)
Summary of all recombinase alleles driven by Lyz2.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Lyz2 Mutation:  40 strains or lines available
References
Original:  J:252269 Canli O, et al., Myeloid Cell-Derived Reactive Oxygen Species Induce Epithelial Mutagenesis. Cancer Cell. 2017 Dec 11;32(6):869-883.e5
All:  12 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory