Hspb7<tm1.2Chen> Targeted Allele Detail MGI Mouse (MGI:6116706)

Hspb7^tm1.2Chen
Targeted Allele Detail

Summary

Symbol:	Hspb7^tm1.2Chen
Name:	heat shock protein family, member 7 (cardiovascular); targeted mutation 1.2, Ju Chen
MGI ID:	MGI:6116706
Synonyms:	HSPB7^-
Gene:	Hspb7 Location: Chr4:141148090-141152621 bp, + strand Genetic Position: Chr4, 74.08 cM, cytoband E1
Alliance:	Hspb7^tm1.2Chen page

General phenotype of Hspb7^tm1.2Chen/Hspb7^tm1.2Chen mice

Show the 6 phenotype image(s) involving this allele.

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:256653
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutation:		Intragenic deletion
		Mutation details: Exon 2 of the gene was flanked by two LoxP sites. Cre-mediated recombination in the germline resulted in the deletion of exon 2. Western blot analysis confirmed the complete absence of protein expression in the hearts of E11.5 homozygous mutant embryos. (J:256653)

Generation of the Hspb7^tm1.1Chen and Hspb7^tm1.2Chen alleles

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Hspb7 Mutation:	14 strains or lines available

References

Original:	J:256653 Wu T, et al., HSPB7 is indispensable for heart development by modulating actin filament assembly. Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):11956-11961
All:	1 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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