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Crhtm1.1(flpo)Bsab
Targeted Allele Detail
Summary
Symbol: Crhtm1.1(flpo)Bsab
Name: corticotropin releasing hormone; targeted mutation 1.1, Bernardo Sabatini
MGI ID: MGI:6116854
Synonyms: Crh-ires-FlpO
Gene: Crh  Location: Chr3:19747565-19749560 bp, - strand  Genetic Position: Chr3, 5.75 cM
Alliance: Crhtm1.1(flpo)Bsab page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:101977
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  (129S6/SvEvTac x C57BL/6J)F1
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Crhtm1.1(flpo)Bsab expression driven by 1 gene
 
Mutation details: The coding sequences for an an internal ribosomal entry site (IRES) followed by an optimized FLP recombinase and a self-excising lox2372-flanked neomycin-Ace-cre cassette are introduced immediately after the Stop codon. In situ characterization demonstrates that flpo and Crh expression completely overlap in the pontine micturition center (PMC) in the pons. (J:101977)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Crh (mouse)
Summary of all recombinase alleles driven by Crh.
 

Expression
In Mice Carrying this Mutation: 11 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Crh Mutation:  42 strains or lines available
References
Original:  J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017;
All:  6 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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11/12/2024
MGI 6.24 		The Jackson Laboratory