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Mgptm1.1(cre)Borr
Targeted Allele Detail
Summary
Symbol: Mgptm1.1(cre)Borr
Name: matrix Gla protein; targeted mutation 1.1, Teresa Borras
MGI ID: MGI:6117343
Synonyms: Mgp-Cre
Gene: Mgp  Location: Chr6:136849433-136852821 bp, - strand  Genetic Position: Chr6, 66.72 cM
Alliance: Mgptm1.1(cre)Borr page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:230973
Parent Cell Line:  PRX-B6N (ES Cell)
Strain of Origin:  C57BL/6NTac
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Mgptm1.1(cre)Borr expression driven by 1 gene
 
Mutation details: The targeting vector was generated by inserting IRES-Cre-FRT-flanked PGK-Neo into BAC RP23-108P5 clone containing mouse Mgp DNA fragment of 8.3 kb following endogenous stop codon. Targeted construct was introduced into ES cells to generate chimera founders. Resulting positive offspring were crossed with a flp deleter line to excise the neomycin resistance gene. (J:230973)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Mgp (mouse)
Summary of all recombinase alleles driven by Mgp.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mgp Mutation:  11 strains or lines available
References
Original:  J:230973 Borras T, et al., A Novel Mgp-Cre Knock-In Mouse Reveals an Anticalcification/Antistiffness Candidate Gene in the Trabecular Meshwork and Peripapillary Scleral Region. Invest Ophthalmol Vis Sci. 2015 Apr;56(4):2203-14
All:  4 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory