Tg(Foxp3*-cre,-Thy1)#Xzhou
Transgene Detail
|
|
| Symbol: |
Tg(Foxp3*-cre,-Thy1)#Xzhou |
| Name: |
transgene insertion, Xuyu Zhou |
| MGI ID: |
MGI:6117456 |
| Synonyms: |
Foxp3 delta CNS1-Cre |
| Transgene: |
Tg(Foxp3*-cre,-Thy1)#Xzhou Location: unknown
|
| Alliance: |
Tg(Foxp3*-cre,-Thy1)#Xzhou page
|
|
| Strain of Origin: |
Not Specified
|
|
| Transgene Type: |
|
Transgenic (Inserted expressed sequence, Recombinase) |
| Mutation: |
|
Insertion
|
| |
|
Tg(Foxp3*-cre,-Thy1)#Xzhou expression driven by
1 gene
Transgene expression driven by:
|
| |
|
Mutation details: Transgene consists of the hCre-2A-eqFP650-2A-Thy1.1 cDNA fragment inserted immediately downstream of the Foxp3 ATG translational start site by homologous recombination into a 188-kb mouse BAC (from the C57BL/6 genome; clone RP23-143D8) carrying the intact Foxp3 gene was used. The CNS1 enhancer in Foxp3 gene was deleted by another round of homologous recombination. The modified BAC was purified and microinjected into the pronuclei of a (B6xB6D2) F1 mouse fertilized ovum to generate transgenic line of mice. Three founder mice were generated and screened for Thy1.1 and endogenous Foxp3 expression.The pound symbol (#) is used when no line is specified and/or lines are pooled.
(J:252233)
|
|
|
|
Activity: |
 Tissue activity of this recombinase allele
|
|
Driver:
|
Foxp3
(mouse)
|
| |
|
|
| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
|
| Original: |
J:252233 Zhang Z, et al., Activation and Functional Specialization of Regulatory T Cells Lead to the Generation of Foxp3 Instability. J Immunol. 2017 Apr 01;198(7):2612-2625 |
| All: |
1 reference(s) |
|
Analysis Tools
