Gfra1tm1.1(cre/ERT2)Cfi
Targeted Allele Detail
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| Symbol: |
Gfra1tm1.1(cre/ERT2)Cfi |
| Name: |
glial cell line derived neurotrophic factor family receptor alpha 1; targeted mutation 1, Carlos F Ibanez |
| MGI ID: |
MGI:6119532 |
| Synonyms: |
Gfra1CreERT2 |
| Gene: |
Gfra1 Location: Chr19:58224036-58444341 bp, - strand Genetic Position: Chr19, 54.18 cM, cytoband D2-D3
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| Alliance: |
Gfra1tm1.1(cre/ERT2)Cfi page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:251552
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| Parent Cell Line: |
Not Specified (ES Cell)
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| Strain of Origin: |
C57BL/6NTac
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| Allele Type: |
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Targeted (Inducible, Recombinase) |
| Inducer: |
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tamoxifen |
| Mutation: |
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Insertion
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Gfra1tm1.1(cre/ERT2)Cfi expression driven by
1 gene
Knock-in expression driven by:
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Mutation details: The targeting vector using bacterial artificial chromosomes (BACs) from the C57BL/6J RPCIB-731 BAC library was constructed by inserting a CreERT2 cassette and F3 flanked puromycin resistant cassette into the second exon of the Gfra1 gene in frame. The vector was transfected into the TaconicArtemis C57BL/6N Tac ESC line to establish mouse line by homologous recombination. Flp-mediated recombination removed the F3-flanked puro cassette.
(J:251552)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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Gfra1
(mouse)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Gfra1 Mutation: |
33 strains or lines available
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| Original: |
J:251552 Sergaki MC, et al., GFRalpha1 Regulates Purkinje Cell Migration by Counteracting NCAM Function. Cell Rep. 2017 Jan 10;18(2):367-379 |
| All: |
3 reference(s) |
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Analysis Tools
