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Trp63tm1.1(cre/ERT2)Jxu
Targeted Allele Detail
Summary
Symbol: Trp63tm1.1(cre/ERT2)Jxu
Name: transformation related protein 63; targeted mutation 2.1, Jianming Xu
MGI ID: MGI:6119568
Synonyms: p63-CreERT2
Gene: Trp63  Location: Chr16:25502513-25710842 bp, + strand  Genetic Position: Chr16, 17.37 cM
Alliance: Trp63tm1.1(cre/ERT2)Jxu page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:249188
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Trp63tm1.1(cre/ERT2)Jxu expression driven by 1 gene
 
Mutation details: The CreERT2-pA-FRT-Neo-FRT was inserted into exon 4 of the Trp63 gene resulting in an in-frame fusion after 115th a.a. of Trp63 isoform. Male chimeric mice were crossbred with female FLPeR mice to remove to remove the Frt-flanked PGK-neo cassette. (J:249188)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Trp63 (mouse)
Summary of all recombinase alleles driven by Trp63.
 

Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Trp63 Mutation:  60 strains or lines available
References
Original:  J:249188 Lee DK, et al., The prostate basal cell (BC) heterogeneity and the p63-positive BC differentiation spectrum in mice. Int J Biol Sci. 2014;10(9):1007-17
All:  14 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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11/12/2024
MGI 6.24 		The Jackson Laboratory