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Asic4tm1.1(cre/ERT2)Cibms
Targeted Allele Detail
Summary
Symbol: Asic4tm1.1(cre/ERT2)Cibms
Name: acid-sensing ion channel family member 4; targeted mutation 1.1, Chih-Cheng Chen
MGI ID: MGI:6120518
Synonyms: Asic4-, Asic4CreERT2, ASIC4-KO/CreERT2
Gene: Asic4  Location: Chr1:75427080-75450987 bp, + strand  Genetic Position: Chr1, 39.08 cM
Alliance: Asic4tm1.1(cre/ERT2)Cibms page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:253311
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Inducible, Null/knockout, Recombinase)
Inducer:    tamoxifen
Mutations:    Insertion, Intragenic deletion
 
Asic4tm1.1(cre/ERT2)Cibms expression driven by 1 gene
 
Mutation details: Thetargeting vector was constructed with the cre/ERT2 gene knocked into the initiator methionine of mouse ASIC4 to replace first 267 amino acid peptides in the N-terminus of ASIC4. A pGK-neo selection cassette flanked by loxP sites was placed downstream of the polyadenylation signal of cre/ERT2. The floxed-pGK-neo cassette was removed by crossing with cre expressing mice. It is a null allele. (J:253311)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Asic4 (mouse)
Summary of all recombinase alleles driven by Asic4.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Asic4 Mutation:  28 strains or lines available
References
Original:  J:253311 Lin SH, et al., Genetic mapping of ASIC4 and contrasting phenotype to ASIC1a in modulating innate fear and anxiety. Eur J Neurosci. 2015 Jun;41(12):1553-68
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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11/12/2024
MGI 6.24 		The Jackson Laboratory