Strip1<cin> Spontaneous Allele Detail MGI Mouse (MGI:6121067)

Strip1^cin
Spontaneous Allele Detail

Summary

Symbol:	Strip1^cin
Name:	striatin interacting protein 1; cinchy
MGI ID:	MGI:6121067
Gene:	Strip1 Location: Chr3:107519848-107539010 bp, - strand Genetic Position: Chr3, 46.83 cM
Alliance:	Strip1^cin page

Mutation
origin

Strain of Origin:

FVB/N

Mutation
description

Allele Type:		Spontaneous (Null/knockout)
Mutation:		Intragenic deletion
		Mutation details: The mutation is a three nucleotide (CTG) in-frame deletion in exon 16. This mutation is predicted to result in the deletion of a leucine residue in a highly conserved stretch of five leucines (amino acids 537541) of the encoded protein. In vitro studies showed that the mutant protein is unstable and is present at 1% of the control level. (J:251816)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Strip1 Mutation:	42 strains or lines available

References

Original:	J:251816 Bazzi H, et al., STRIP1, a core component of STRIPAK complexes, is essential for normal mesoderm migration in the mouse embryo. Proc Natl Acad Sci U S A. 2017 Dec 19;114(51):E10928-E10936
All:	1 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24