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Col1a1tm1(CMV/tetO-Kdm2b)Atz
Targeted Allele Detail
Summary
Symbol: Col1a1tm1(CMV/tetO-Kdm2b)Atz
Name: collagen, type I, alpha 1; targeted mutation 1, Alexandros Tzatsos
MGI ID: MGI:6121397
Synonyms: Tet-Kdm2b
Gene: Col1a1  Location: Chr11:94827050-94843868 bp, + strand  Genetic Position: Chr11, 59.01 cM, cytoband D
Alliance: Col1a1tm1(CMV/tetO-Kdm2b)Atz page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:232437
Parent Cell Line:  KH2 (ES Cell)
Strain of Origin:  (C57BL/6 x 129S4/SvJae)F1
Mutation
description
Allele Type:    Targeted (Inducible, Inserted expressed sequence)
Inducer:    doxycycline/tetracycline
Mutation:    Insertion
 
Col1a1tm1(CMV/tetO-Kdm2b)Atz expresses 1 gene
 
Mutation detailsThe construct contains Kdm2b cDNA under the control of the CMV promoter fused with the tet-responsive element (tetO) which was co-electroporated into KH2 embryonic stem cells along with a plasmid expressing Flpe recombinase to allow FRT/Flpase-mediated single copy site-specific integration into the locus. (J:232437)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Col1a1 Mutation:  163 strains or lines available
Notes
This allele was generated with Col1a1tm13(neo/hygro*)Jae.
References
Original:  J:232437 Andricovich J, et al., Histone demethylase KDM2B regulates lineage commitment in normal and malignant hematopoiesis. J Clin Invest. 2016 Mar 1;126(3):905-20
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory