Col1a1tm2(CMV/tetO-Kdm2b*)Atz
Targeted Allele Detail
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| Symbol: |
Col1a1tm2(CMV/tetO-Kdm2b*)Atz |
| Name: |
collagen, type I, alpha 1; targeted mutation 2, Alexandros Tzatsos |
| MGI ID: |
MGI:6121399 |
| Synonyms: |
Tet-Kdm2bdeltaJmjc |
| Gene: |
Col1a1 Location: Chr11:94827050-94843868 bp, + strand Genetic Position: Chr11, 59.01 cM, cytoband D
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| Alliance: |
Col1a1tm2(CMV/tetO-Kdm2b*)Atz page
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| Allele Type: |
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Targeted (Inducible, Inserted expressed sequence) |
| Inducer: |
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doxycycline/tetracycline |
| Mutation: |
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Insertion
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Col1a1tm2(CMV/tetO-Kdm2b*)Atz expresses
1 gene
Knock-in expresses:
| Organism |
Expressed Gene |
Note |
| Not Specified |
Kdm2b |
Expresses a demethylation deficient form |
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Mutation details: The construct contains cDNA of demethylation deficient Kdm2b under the control of the CMV promoter fused with the tet-responsive element (tetO) which was co-electroporated into KH2 embryonic stem cells along with a plasmid expressing Flpe recombinase to allow FRT/Flpase-mediated single copy site-specific integration into the locus.
(J:232437)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Col1a1 Mutation: |
163 strains or lines available
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| Original: |
J:232437 Andricovich J, et al., Histone demethylase KDM2B regulates lineage commitment in normal and malignant hematopoiesis. J Clin Invest. 2016 Mar 1;126(3):905-20 |
| All: |
1 reference(s) |
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Analysis Tools
