About   Help   FAQ
Col15a1tm2.1Pih
Targeted Allele Detail
Summary
Symbol: Col15a1tm2.1Pih
Name: collagen, type XV, alpha 1; targeted mutation 2.1, Taina Pihlajaniemi
MGI ID: MGI:6147361
Synonyms: loxP flanked allele
Gene: Col15a1  Location: Chr4:47208161-47313167 bp, + strand  Genetic Position: Chr4, 26.01 cM, cytoband B1-B3
Alliance: Col15a1tm2.1Pih page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:82809
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready)
Mutation:    Insertion
 
Mutation details: A loxP site was introduced ~900 bp upstream of exon 1 and a loxP-flanked neomycin resistance cassette 120 bp downstream of exon 2. Cre recombinase deleted the selection cassette, leaving exons 1 and 2, encoding the first 33 amino acids of the protein, flanked by loxP sites. This allele was derived from the same targeting event as Col15a1tm1Pih. (J:67212)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Col15a1 Mutation:  71 strains or lines available
References
Original:  J:67212 Eklund L, et al., Lack of type XV collagen causes a skeletal myopathy and cardiovascular defects in mice. Proc Natl Acad Sci U S A. 2001 Jan 30;98(3):1194-9
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory