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Col15a1tm2.1Pih
Targeted Allele Detail
Summary
Symbol: Col15a1tm2.1Pih
Name: collagen, type XV, alpha 1; targeted mutation 2.1, Taina Pihlajaniemi
MGI ID: MGI:6147361
Synonyms: loxP flanked allele
Gene: Col15a1  Location: Chr4:47208161-47313167 bp, + strand  Genetic Position: Chr4, 26.01 cM, cytoband B1-B3
Alliance: Col15a1tm2.1Pih page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:82809
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready)
Mutation:    Insertion
 
Mutation details: A loxP site was introduced ~900 bp upstream of exon 1 and a loxP-flanked neomycin resistance cassette 120 bp downstream of exon 2. Cre recombinase deleted the selection cassette, leaving exons 1 and 2, encoding the first 33 amino acids of the protein, flanked by loxP sites. This allele was derived from the same targeting event as Col15a1tm1Pih. (J:67212)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Col15a1 Mutation:  71 strains or lines available
References
Original:  J:67212 Eklund L, et al., Lack of type XV collagen causes a skeletal myopathy and cardiovascular defects in mice. Proc Natl Acad Sci U S A. 2001 Jan 30;98(3):1194-9
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory