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Zcchc17tm1Pou
Targeted Allele Detail
Summary
Symbol: Zcchc17tm1Pou
Name: zinc finger, CCHC domain containing 17; targeted mutation 1, Pin Ouyang
MGI ID: MGI:6147733
Synonyms: deltaE2
Gene: Zcchc17  Location: Chr4:130209176-130253736 bp, - strand  Genetic Position: Chr4, 63.43 cM
Alliance: Zcchc17tm1Pou page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:233160
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Modified isoform(s))
Mutation:    Insertion
 
Mutation detailsA PGK-beta-geo (beta-galactosidase-neomycin fusion gene) selection cassette was inserted into exon 2, disrupting the first ATG that gives rise to the long isoform. RT-PCR indicates enhanced mRNA expression of the short isoform (which uses an ATG in exon 4) and disrupted expression of the long isoform. (J:233160)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Zcchc17 Mutation:  25 strains or lines available
References
Original:  J:233160 Lin YM, et al., Target disruption of ribosomal protein pNO40 accelerates aging and impairs osteogenic differentiation of mesenchymal stem cells. Biochem Biophys Res Commun. 2016 Jan 22;469(4):903-10
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory