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Zfyve27tm1.1(cre/ERT2)Qaa
Targeted Allele Detail
Summary
Symbol: Zfyve27tm1.1(cre/ERT2)Qaa
Name: zinc finger, FYVE domain containing 27; targeted mutation 1, Qais Al-Awqati
MGI ID: MGI:6148981
Synonyms: Zfyve27-CreERT2
Gene: Zfyve27  Location: Chr19:42159006-42183032 bp, + strand  Genetic Position: Chr19, 35.87 cM
Alliance: Zfyve27tm1.1(cre/ERT2)Qaa page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:259138
Parent Cell Line:  KV1 (ES Cell)
Strain of Origin:  (C57BL/6J x 129S6/SvEvTac)F1
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Zfyve27tm1.1(cre/ERT2)Qaa expression driven by 1 gene
 
Mutation details: A targeting vector was designed to insert a cre/ERT2 cassette followed by an FRT-flanked neo cassette into the ATG codon of mouse Zfyve27 gene via homologous recombination in ES cells. The resulting chimeric animals were bred to germline-active ACTB-Flpe deleter transgenic mice to delete the FRT5-flanked neo cassette. (J:259138)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Zfyve27 (mouse)
Summary of all recombinase alleles driven by Zfyve27.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Zfyve27 Mutation:  25 strains or lines available
References
Original:  J:259138 Oliver JA, et al., A Subpopulation of Label-Retaining Cells of the Kidney Papilla Regenerates Injured Kidney Medullary Tubules. Stem Cell Reports. 2016 May 10;6(5):757-771
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
07/02/2024
MGI 6.13 		The Jackson Laboratory