Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Krastm1.1Khai
Name:	Kirsten rat sarcoma viral oncogene homolog; targeted mutation 1.1, Kevin Haigis
MGI ID:	MGI:6149500
Synonyms:	KrasLSL-A146T
Gene:	Kras  Location: Chr6:145162425-145195965 bp, - strand  Genetic Position: Chr6, 77.37 cM, cytoband G2
Alliance:	Krastm1.1Khai page

Germline Transmission:	Earliest citation of germline transmission: J:276349
Parent Cell Line:	TL1/TL-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Conditional ready, Humanized sequence) Mutation:    Nucleotide substitutions   Mutation details: The targeting vector is designed to insert a loxP site flanked STOP cassette into intron 1. Exon 4 was modified to change alanine codon 146 to threonine (p.A146T), a mutation commonly found in patients with cancers of the gastrointestinal tract and blood. An FRT site flanked neomycin resistance gene cassette is placed into intron 4. Flp-mediated recombination removed the neo cassette. (J:276349)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

6 anatomical structure(s)

List all tumor models in MMHCdb carrying Krastm1.1Khai

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Kras Mutation:	84 strains or lines available

Original:	J:276349 Poulin EJ, et al., Tissue-Specific Oncogenic Activity of KRAS(A146T). Cancer Discov. 2019 Jun;9(6):738-755
All:	1 reference(s)