Tg(Gnat3*G352P)82Rfm
Transgene Detail
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| Symbol: |
Tg(Gnat3*G352P)82Rfm |
| Name: |
transgene insertion 82, Robert F Margolskee |
| MGI ID: |
MGI:6150893 |
| Transgene: |
Tg(Gnat3*G352P)82Rfm Location: unknown
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| Alliance: |
Tg(Gnat3*G352P)82Rfm page
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| Strain of Origin: |
B6CBAF1
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(Gnat3*G352P)82Rfm expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| rat |
Gnat3 (286924) |
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includes a G325P mutation |
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Mutation details: An 8.4-kb fragment of the mouse alpha-gustducin gene (GUS8.4 promoter) that drives taste receptor cell-specific expression was cloned 5 to the rat mutated G352P-alpha-gustducin cDNA. The mutation is a single glycine to proline substitution at position 352 near its C terminus (G352P). Three lines of mice (nos. 81, 82, and 89) were generated. Line 82 was chosen for further analysis because the pattern of alpha-gustducin expression matched or exceeded that of WT.
(J:128673)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:128673 Ruiz-Avila L, et al., Dominant loss of responsiveness to sweet and bitter compounds caused by a single mutation in alpha -gustducin. Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8868-73 |
| All: |
2 reference(s) |
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Analysis Tools
