Oxtrtm1.1(cre)Hze
Targeted Allele Detail
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| Symbol: |
Oxtrtm1.1(cre)Hze |
| Name: |
oxytocin receptor; targeted mutation 1.1, Hongkui Zeng |
| MGI ID: |
MGI:6150896 |
| Synonyms: |
Oxtr-T2A-Cre-D |
| Gene: |
Oxtr Location: Chr6:112450644-112466904 bp, - strand Genetic Position: Chr6, 52.27 cM, cytoband E3
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| Alliance: |
Oxtrtm1.1(cre)Hze page
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| Allele Type: |
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Targeted (Recombinase) |
| Mutation: |
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Insertion
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Oxtrtm1.1(cre)Hze expression driven by
1 gene
Knock-in expression driven by:
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Mutation details: The targeting vector contained, from 5' to 3', a partial Oxtr sequence spanning intron 1 up to but not including the endogenous stop codon in exon 2 (with a frt3 site in intron 1), a viral 2A oligopeptide sequence (T2A; mediates ribosomal skipping), a Cre recombinase gene, a bovine growth hormone polyA sequence, an AttB site, a PGK/gb2 promoter-Neomycin resistance gene-PGK polyA cassette, a frt5 site, an mRNA splice acceptor sequence, the 3' portion of the hygromycin gene (Hygro2) with SV40 polyA signal, and an AttP site. PhiC31-mediated recombination removed the AttB/AttP-flanked sequences (PGK/gb2-Neo-pA::frt5::RNA splice acceptor::3'hygro-pA) and replace it with the recombined AttB/AttP site (AttL).
(J:260362)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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Oxtr
(mouse)
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| Original: |
J:260362 Daigle TL, et al., A suite of transgenic driver and reporter mouse lines with enhanced brain cell type targeting and functionality. Cell. 2018 Jul 12;174(2):465-480.e22 |
| All: |
13 reference(s) |
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Analysis Tools
