Npr3tm1.1(cre)Hze
Targeted Allele Detail
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| Symbol: |
Npr3tm1.1(cre)Hze |
| Name: |
natriuretic peptide receptor 3; targeted mutation 1.1, Hongkui Zeng |
| MGI ID: |
MGI:6150901 |
| Synonyms: |
Npr3-IRES2-Cre-D, Npr3-IRES2-Cre-Delta, Npr3-IRES2-Cre-Deltaneo |
| Gene: |
Npr3 Location: Chr15:11839982-11907287 bp, - strand Genetic Position: Chr15, 5.83 cM
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| Alliance: |
Npr3tm1.1(cre)Hze page
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| Allele Type: |
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Targeted (Recombinase) |
| Mutation: |
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Insertion
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Npr3tm1.1(cre)Hze expression driven by
1 gene
Knock-in expression driven by:
| Organism |
Driver Gene |
Note |
| mouse |
Npr3 (MGI:97373) |
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Mutation details: The targeting vector contained, from 5' to 3', a partial Npr3 sequence spanning intron 6 up to and including the endogenous stop codon in exon 8 (also with a frt3 site in intron 7), an internal ribosome entry site 2 sequence (IRES2; allows translation initiation in the middle of an mRNA sequence), a Cre recombinase gene, a bovine growth hormone polyA sequence, an AttB site, a PGK/gb2 promoter-Neomycin resistance gene-PGK polyA cassette, a frt5 site, an mRNA splice acceptor sequence, the 3' portion of the hygromycin gene (Hygro2) with SV40 polyA signal, and an AttP site. PhiC31-mediated recombination removed the AttB/AttP-flanked sequences (PGK/gb2-Neo-pA::frt5::RNA splice acceptor::3'hygro-pA) and replace it with the recombined AttB/AttP site (AttL).
(J:260362)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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Npr3
(mouse)
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| Original: |
J:260362 Daigle TL, et al., A suite of transgenic driver and reporter mouse lines with enhanced brain cell type targeting and functionality. Cell. 2018 Jul 12;174(2):465-480.e22 |
| All: |
8 reference(s) |
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Analysis Tools
