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Mitftm1.1(cre)Mwka
Targeted Allele Detail
Summary
Symbol: Mitftm1.1(cre)Mwka
Name: melanogenesis associated transcription factor; targeted mutation 1.1, Mari Wataya-Kaneda
MGI ID: MGI:6151122
Synonyms: Mitf-Cre
Gene: Mitf  Location: Chr6:97784013-97998310 bp, + strand  Genetic Position: Chr6, 45.05 cM
Alliance: Mitftm1.1(cre)Mwka page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:259390
Parent Cell Line:  KY1.1 (ES Cell)
Strain of Origin:  (C57BL/6J x 129S6/SvEvTac)F1
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Mitftm1.1(cre)Mwka expression driven by 1 gene
 
Mutation details: A cre cassette was inserted into exon 1 of Mitf gene. This allele contains a single loxP sites and a frt site after removal of neomycin selection cassette. (J:259390)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Mitf (mouse)
Summary of all recombinase alleles driven by Mitf.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mitf Mutation:  74 strains or lines available
References
Original:  J:259390 Yang F, et al., Uncoupling of ER/Mitochondrial Oxidative Stress in mTORC1 Hyperactivation-Associated Skin Hypopigmentation. J Invest Dermatol. 2018 Mar;138(3):669-678
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory