Col1a1<tm2(tetO-URI1*S371A)Ndj> Targeted Allele Detail MGI Mouse (MGI:6154714)

Col1a1^{tm2(tetO-URI1*S371A)Ndj}
Targeted Allele Detail

Summary

Symbol:	Col1a1^{tm2(tetO-URI1*S371A)Ndj}
Name:	collagen, type I, alpha 1; targeted mutation 2, Nabil Djouder
MGI ID:	MGI:6154714
Gene:	Col1a1 Location: Chr11:94827050-94843868 bp, + strand Genetic Position: Chr11, 59.01 cM, cytoband D
Alliance:	Col1a1^{tm2(tetO-URI1*S371A)Ndj} page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:234982
Parent Cell Line:	KH2 (ES Cell)
Strain of Origin:	(C57BL/6 x 129S4/SvJae)F1

Mutation
description

Allele Type:

Targeted (Humanized sequence, Inducible, Inserted expressed sequence)

Inducer:

doxycycline/tetracycline

Mutation:

Insertion

Col1a1^{tm2(tetO-URI1*S371A)Ndj} expresses 1 gene

Mutation details: A construct containing an FRT site, tetO sequence, FLAG tagged human URI1 cDNA containing the S371A mutation, and FRT site was inserted in KH2 ES cells. The S371A mutation generates a non-phosphorylatable form of the protein. (J:234982)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Col1a1 Mutation:	163 strains or lines available

Notes

This allele was generated with Col1a1^{tm13(neo/hygro*)Jae}.

References

Original:	J:234982 Buren S, et al., Regulation of OGT by URI in Response to Glucose Confers c-MYC-Dependent Survival Mechanisms. Cancer Cell. 2016 Aug 8;30(2):290-307
All:	1 reference(s)

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