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Tg(hs192-cre/ERT2,-GFP)1040Jlr
Transgene Detail
Summary
Symbol: Tg(hs192-cre/ERT2,-GFP)1040Jlr
Name: transgene insertion 1040, John Rubenstein
MGI ID: MGI:6160853
Synonyms: 192-CreER-IRES-GFP
Transgene: Tg(hs192-cre/ERT2,-GFP)1040Jlr  Location: unknown  
Alliance: Tg(hs192-cre/ERT2,-GFP)1040Jlr page
Transgene
origin
Strain of Origin:  FVB/NJ
Transgene
description
Transgene Type:    Transgenic (Inducible, Recombinase, Reporter)
Inducer:    tamoxifen
Mutation:    Insertion
 
Tg(hs192-cre/ERT2,-GFP)1040Jlr expression driven by 1 gene
 
Mutation detailsThis transgene contains the human enhancer element hs192 -- which is flanked on human Chr 3 by the DnaJ heat shock protein family (Hsp40) member C19 (DNAJC19) and SOX2 overlapping transcript (non-protein coding) (SOX2-OT) loci -- followed by a mouse minimal Hsp68 promoter, the cre/ERT2 fusion gene, an internal ribosomal entry site (IRES), and a green fluorescent protein reporter gene. The fusion gene encodes Cre recombinase joined to a modified ligand-binding domain of the human estrogen receptor that preferentially binds tamoxifen or 4-hydroxytamoxifen, but not endogenous 17beta-estradiol; upon binding to tamoxifen, the cre/ERT2 protein is translocated to the nucleus. (J:214335)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: hs192 (human)
Summary of all recombinase alleles driven by hs192.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:214335 Pattabiraman K, et al., Transcriptional regulation of enhancers active in protodomains of the developing cerebral cortex. Neuron. 2014 Jun 4;82(5):989-1003
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory