Tg(hs660-cre/ERT2,-GFP)847Jlr
Transgene Detail
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| Symbol: |
Tg(hs660-cre/ERT2,-GFP)847Jlr |
| Name: |
transgene insertion 847, John Rubenstein |
| MGI ID: |
MGI:6160939 |
| Synonyms: |
660-CreER-IRES-GFP |
| Transgene: |
Tg(hs660-cre/ERT2,-GFP)847Jlr Location: unknown
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| Alliance: |
Tg(hs660-cre/ERT2,-GFP)847Jlr page
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| Transgene Type: |
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Transgenic (Inducible, Recombinase, Reporter) |
| Inducer: |
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tamoxifen |
| Mutation: |
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Insertion
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Tg(hs660-cre/ERT2,-GFP)847Jlr expression driven by
1 gene
Transgene expression driven by:
| Organism |
Driver Gene |
Note |
| human |
hs660 |
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Mutation details: This transgene contains the human enhancer element hs660 -- which is flanked on human Chr 15 by the SMAD family member 6 (SMAD6) and SMAD family member 3 (SMAD3) loci -- followed by a mouse minimal Hsp68 promoter, the cre/ERT2 fusion gene, an internal ribosomal entry site (IRES), and a green fluorescent protein reporter gene. The fusion gene encodes Cre recombinase joined to a modified ligand-binding domain of the human estrogen receptor that preferentially binds tamoxifen or 4-hydroxytamoxifen, but not endogenous 17beta-estradiol; upon binding to tamoxifen, the cre/ERT2 protein is translocated to the nucleus.
(J:214335)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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hs660
(human)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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| Original: |
J:214335 Pattabiraman K, et al., Transcriptional regulation of enhancers active in protodomains of the developing cerebral cortex. Neuron. 2014 Jun 4;82(5):989-1003 |
| All: |
1 reference(s) |
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Analysis Tools
