Tg(hs840-cre/ERT2,-GFP)75Jlr
Transgene Detail
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| Symbol: |
Tg(hs840-cre/ERT2,-GFP)75Jlr |
| Name: |
transgene insertion 75, John Rubenstein |
| MGI ID: |
MGI:6160942 |
| Synonyms: |
840-CreER-IRES-GFP, Tg(CENPC-cre/ERT2, GFP)75Jlr |
| Transgene: |
Tg(hs840-cre/ERT2,-GFP)75Jlr Location: unknown
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| Alliance: |
Tg(hs840-cre/ERT2,-GFP)75Jlr page
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| Transgene Type: |
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Transgenic (Inducible, Recombinase, Reporter) |
| Inducer: |
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tamoxifen |
| Mutation: |
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Insertion
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Tg(hs840-cre/ERT2,-GFP)75Jlr expression driven by
1 gene
Transgene expression driven by:
| Organism |
Driver Gene |
Note |
| human |
hs840 |
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Mutation details: This transgene contains the human enhancer element hs840 -- which is flanked on human Chr 4 by the EPHA5 [EPH receptor A5] antisense RNA 1 (EPHA5-AS1) and Homo sapiens uncharacterized LOC101927237 long non-coding RNA (LOC101927237) loci -- followed by a mouse minimal Hsp68 promoter, the cre/ERT2 fusion gene, an internal ribosomal entry site (IRES), and a green fluorescent protein reporter gene. The fusion gene encodes Cre recombinase joined to a modified ligand-binding domain of the human estrogen receptor that preferentially binds tamoxifen or 4-hydroxytamoxifen, but not endogenous 17beta-estradiol; upon binding to tamoxifen, the cre/ERT2 protein is translocated to the nucleus.
(J:214335)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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hs840
(human)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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| Original: |
J:214335 Pattabiraman K, et al., Transcriptional regulation of enhancers active in protodomains of the developing cerebral cortex. Neuron. 2014 Jun 4;82(5):989-1003 |
| All: |
1 reference(s) |
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Analysis Tools
