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Katnal2m1Anu
Chemically induced Allele Detail
Summary
Symbol: Katnal2m1Anu
Name: katanin p60 subunit A-like 2; mutation 1, Australian National University
MGI ID: MGI:6164198
Synonyms: Katnal2Y86C
Gene: Katnal2  Location: Chr18:77064844-77135004 bp, - strand  Genetic Position: Chr18, 52.02 cM, cytoband E3
Alliance: Katnal2m1Anu page
Sperm abnormalities in Katnal2m1Anu/Katnal2m1Anu mice

Show the 5 phenotype image(s) involving this allele.

Mutation
origin
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Chemically induced (ENU) (Not Specified)
Mutation:    Single point mutation
 
Mutation details: The molecular lesion is an A-to-G substitution in codon 86 within exon3, resulting in the substitution of tyrosine (TAC) to cysteine (TGC) in the encoded protein. qPCR analysis of mRNA transcript levels in whole testis homogenates revealed no difference between homozygous mutant mice and wild-type controls. However, Western blot analysis of the 46 kDa isoform in whole testis homogenates revealed that protein expression is reduced to 41% of wild-type levels. (J:250115)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Katnal2 Mutation:  201 strains or lines available
References
Original:  J:250115 Dunleavy JEM, et al., Katanin-like 2 (KATNAL2) functions in multiple aspects of haploid male germ cell development in the mouse. PLoS Genet. 2017 Nov;13(11):e1007078
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory