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Gt(ROSA)26Sortm1.1(CAG-Cerulean/Arl13b,-Venus/GMNN,-Cherry/CDT1)Rmort
Targeted Allele Detail
Summary
Symbol: Gt(ROSA)26Sortm1.1(CAG-Cerulean/Arl13b,-Venus/GMNN,-Cherry/CDT1)Rmort
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1.1, Richard Mort
MGI ID: MGI:6193734
Synonyms: R26Arl13b-Fucci2a
Gene: Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance: Gt(ROSA)26Sortm1.1(CAG-Cerulean/Arl13b,-Venus/GMNN,-Cherry/CDT1)Rmort page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:267034
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Reporter)
Mutation:    Insertion
 
Mutation details: Sequences include CMV enhancer/chicken beta-actin promoter (CAG), a loxP-STOP(3xSV40 polyA)-loxP cassette (LSL), full-length mouse Arl13b cDNA (OTTMUST00000058920.GRCm38) fused to mCerulean and Fucci2a using the porcine teschovirus-1 2A (P2A) ribosomal skip cleavage peptide sequence on the N-terminus of the Fucci2a cell cycle probe consisting of a fusion of mCherry with a truncated human CDT1 (aa 30-120) fused to mCherry and mVenus fused to 110aa N-terminal human Geminin fragmentand a bovine growth hormone polyA sequence (BGHpA). Cre-mediated recombination removed the STOP cassette. (J:267034)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  993 strains or lines available
References
Original:  J:267034 Ford MJ, et al., A Cell/Cilia Cycle Biosensor for Single-Cell Kinetics Reveals Persistence of Cilia after G1/S Transition Is a General Property in Cells and Mice. Dev Cell. 2018 Nov 19;47(4):509-523.e5
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory