Lyz2<em1.1(cre)Elgaz> Endonuclease-mediated Allele Detail MGI Mouse (MGI:6195189)

Lyz2^{em1.1(cre)Elgaz}
Endonuclease-mediated Allele Detail

Summary

Symbol:	Lyz2^{em1.1(cre)Elgaz}
Name:	lysozyme 2; endonuclease-mediated mutation 1.1, Mohamed Elgazzar
MGI ID:	MGI:6195189
Synonyms:	Lyz2-Cre, Lyz2^em1.1Elgaz
Gene:	Lyz2 Location: Chr10:117113446-117118177 bp, - strand Genetic Position: Chr10, 65.34 cM
Alliance:	Lyz2^{em1.1(cre)Elgaz} page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:244204
Parent Cell Line:	Other (see notes) (ES Cell)
Strain of Origin:	BALB/cJ

Mutation
description

Allele Type:

Endonuclease-mediated (Recombinase)

Mutation:

Insertion

Lyz2^{em1.1(cre)Elgaz} expression driven by 1 gene

Mutation details: CRISPR/cas9 endonuclease mediated genome editing is used to introduce a nucleus-localized (NLS) Cre recombinase followed by a FRT-flanked neomycin cassette into the ATG start codon of the gene. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:244204)

Recombinase
activity

Activity:	Tissue activity of this recombinase allele
Driver:	Lyz2 (mouse) Summary of all recombinase alleles driven by Lyz2. Alliance mouse Lyz2 gene page

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Lyz2 Mutation:	40 strains or lines available

Notes

ES Cell Line = PRX-BALB/cJ 9

References

Original:	J:244204 McPeak MB, et al., Myeloid Cell-Specific Knockout of NFI-A Improves Sepsis Survival. Infect Immun. 2017 Apr;85(4)
All:	3 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24